Monoamine oxidase inhibitors (MAOIs) are considered to be perhaps the most effective antidepressant agents in the psychiatrist's medical arsenal. They work by inhibiting the enzyme monoamine oxidase in the brain. Selective serotonin reuptake inhibitors (SSRIs), on the other hand, are used to treat depression in addition to many anxiety-related illnesses, including panic disorder (PD). They work by inhibiting the reuptake of serotonin in the brain, causing an increase of serotonin. It is believed that the brain contains several hundred different types of chemical messengers (neurotransmitters) that act as communication agents between different brain cells. These chemical messengers are molecular substances that can affect mood, appetite, anxiety, sleep, heart rate, temperature, aggression, fear, and many other psychological and physical occurrences. Monoamine oxidase (MAO) is an enzyme that degrades or breaks down three neurotransmitters associated with mood and anxiety: serotonin, norepinephrine, and dopamine. Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed. They're effective, but they've generally been replaced by antidepressants that are safer and cause fewer side effects. Use of typically requires diet restrictions because they can cause dangerously high blood pressure when taken with certain foods or medications. In spite of side effects, these medications are still a good option for some people. In certain cases, they relieve depression when other treatments have failed. requires that all antidepressants carry black box warnings, the strictest warnings for prescriptions. In some cases, children, teenagers and young adults under 25 may have an increase in suicidal thoughts or behavior when taking antidepressants, especially in the first few weeks after starting or when the dose is changed.
These highlights do not include all the information needed to use ZOLOFT safely and effectively. ZOLOFT (sertraline hydrochloride) tablets, for oral use ZOLOFT (sertraline hydrochloride) oral solution Initial U. Approval: 1991Most common adverse reactions (≥5% and twice placebo) in pooled placebo-controlled MDD, OCD, PD, PTSD, SAD and PMDD clinical trials were nausea, diarrhea/loose stool, tremor, dyspepsia, decreased appetite, hyperhidrosis, ejaculation failure, and decreased libido (6.1) Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. A dosage of 25 mg or 50 mg per day is the initial therapeutic dosage. For adults and pediatric patients, subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day. Given the 24-hour elimination half-life of ZOLOFT, the recommended interval between dose changes is one week. The recommended starting ZOLOFT dosage in adult women with PMDD is 50 mg per day. ZOLOFT may be administered either continuously (every day throughout the menstrual cycle) or intermittently (only during the luteal phase of the menstrual cycle, i.e., starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses). The FDA has approved sertraline for the treatment of depression, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder (SAD). Sertraline is also used for a number of other problems, such as: Sertraline has been approved to treat severe OCD in children between the ages of 6 and 17. Therapy is usually started at 50 mg/day and the dose is increased at weekly intervals if necessary. Children and older people often need smaller doses of medication and may start with 25 mg/day. People with liver disease may need a smaller dose of sertraline. We don't know exactly what causes depression and other mental health problems, but one theory that is pretty well-accepted is that there is chemical imbalance in the brain and nervous tissue. Several chemicals called neurotransmitters help nerve cells communicate, and serotonin is one of those chemicals. Nerve impulses cause the cell to release serotonin. The serotonin travels across the gap between cells and attaches to the other cell. Sertraline is a serotonin selective reuptake inhibitor; it keeps serotonin from being reabsorbed and allows it to accumulate, restoring chemical balance.
Zoloft and Cymbalta can treat multiple conditions, some of which are approved by the Food and Drug Adminstration and some of which are off-label. For example, Zoloft is approved for use in major depression; premenstrual dysphoric disorder; social anxiety disorder; obsessive-compulsive disorder; panic disorder and post-traumatic depression. Some off-label uses include autism, Tourette syndrome, fibromyalgia, migraines, dementia, obesity, diabetic neuropathy, premature ejaculation, anorexia, bulimia, personality disorders, hot flashes and generalized anxiety disorder. Cymbalta has been approved to treat depression, generalized anxiety disorder, fibromyalgia, and pain from diabetic neuropathy . Off-label include treating other types of chronic pain and stress incontinence. explains that patients with certain conditions may need to undergo testing or receive a dose adjustment in order for them to take these drugs safely. For example, restrictions for Zoloft and Cymbalta use exist for patients with liver or kidney disease, epilepsy, bipolar disorder, or those with a history of drug abuse or suicidal thoughts. Patients with glaucoma or bleeding disorders may also have to undergo testing before starting Cymbalta. ZOLOFT is also indicated to treat children with OCD age 6 to 17 years. If you have a prescription for brand-name ZOLOFT, you can use the card for every fill through December 31, 2020. It is important to talk with your doctor about the risks of treating depression and also the risks of not treating it. Many antidepressant medicines including ZOLOFT may cause a certain type of eye problem called angle-closure glaucoma. Children and adolescents should have height and weight monitored during treatment. The Card is not valid for California residents whose prescriptions are covered in whole or in part by third-party insurance, a healthcare service plan, or other health coverage where a lower cost generic is available, unless applicable step therapy or prior authorization requirements have been completed. You should discuss all treatment choices with your doctor. Call your healthcare provider if you have eye pain, changes in your vision, or swelling or redness in or around the eye. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Please check with your healthcare professional or insurer to confirm eligibility. Talk to your doctor if you do not think that your condition is getting better with ZOLOFT treatment. Yes, for reimbursement when using a nonparticipating pharmacy: Pay for your ZOLOFT prescription, and mail a copy of the original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: ZOLOFT Savings Card, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560. ZOLOFT and other antidepressant medicines may cause serious side effects. Be sure to include a copy of the front of your ZOLOFT Savings Card, your name, and mailing address. Call your healthcare provider right away if you have any of the following symptoms, or call 911 if there is an emergency. Yes, for reimbursement when using the ZOLOFT Savings Card through a mail-order pharmacy: Pay for your ZOLOFT prescription, and mail a copy of the original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: ZOLOFT Savings Card, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560. Symptoms may include: The ZOLOFT Savings Card allows eligible patients to pay as little as $4 every time they get a 30-day fill of brand-name ZOLOFT—and could save up to $1,800 a year.
ZOLOFT- sertraline hydrochloride tablet, film coated ZOLOFT- sertraline hydrochloride solution, concentrate Roerig----- Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors SSRIs.