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Dizziness (4-9%) Somnolence (4-8%) Fatigue (4-7%; dose related) Nausea (4-6%) Asthenia (1-5%) Hot flashes (1-5%) Paresthesia (3-4%) Dry mouth (3%) Chest pain (2-3%) Pain/pressure in chest, neck, throat, jaw ( Tachycardia Angioedema Wheezing Hypertensive crisis Bradycardia Hallucination Epidermal necrolysis Hearing impairment Arrhythmias Myocardial infarction and coronary artery vasospasm in patients with CAD risk factors Hypersensitivity Ischemic heart disease, uncontrolled hypertension, or other significant cardiovascular disease Coronary artery vasospasm History of stroke or transient ischemic attack Ischemic bowel Peripheral vascular disease Basilar or hemiplegic migraine Within 24 hours of another 5-HT1 agonist or ergot derivative Within 2 weeks of MAOI Use caution in hepatic/renal insufficiency Overuse of acute migraine drugs (eg, ergotamine, triptans, opioids, or combination of these drugs for ≥10 days/month) may lead to exacerbation of headache (medication overuse headache) Potentially life-threatening serotonin syndrome may occur, particularly during combined use with SSRIs (eg, fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram) or SNRIs (eg, venlafaxine, duloxetine) Coronary artery vasospasm, ventricular tachycardia/fibrillation, cardiac arrest, myocardial infarction, transient ischemia, and death reported with the use of 5-HT1 agonists Cerebral/subarachnoid hemorrhage and stroke reported with the use of 5-HT1 agonists Significant hypertension or hypertensive crisis reported in patients with and without history of hypertension Not for use in the prevention of migraine or the treatment of cluster headaches Maxalt-MLT tablets contain phenylalanine (not for use in patients with phenylketonuria) Patients with sensations of chest pain/pressure/tightness or symptoms suggestive of angina following dosing should be evaluated for coronary artery disease or Prinzmetal’s angina before administering additional doses; monitor with ECG if dosing is resumed and similar symptoms occur Peripheral vascular ischemia and colonic ischemia, gastrointestinal ischemia/infarction, splenic infarction, and Raynaud’s syndrome reported with 5-HT1 agonist Transient or permanent partial vision loss and blindness reported (rare) Not for administration to patients who have risk factors for coronary artery disease (CAD), including hypertension, obesity, hypercholesterolemia, diabetes, menopause, strong family history of CAD, male 40 years of age or is a smoker unless patient undergoes adequate cardiac evaluation; patients suspected of having CAD, should have CAD ruled out before considering use of drug; if evaluation satisfactory, first dose should be administered in the healthcare provider’s office; perform periodic evaluation of cardiovascular status in all patients The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Maxalt (rizatriptan) is a headache medicine that narrows the blood vessels around the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Maxalt will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Maxalt should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches. You should not use Maxalt if you have uncontrolled high blood pressure, heart problems, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not take Maxalt within 24 hours before or after using another migraine headache medicine.
Maxalt® 10 mg Tablets Rizatriptan 10 mg Tablets 2475  (rizatriptan) PATIENT INFORMATION LEAFLET Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you. This includes any possible side effects not listed in this leaflet. Your medicine is known as one of the above names but will be referred to as Maxalt throughout the leaflet. Warnings and precautions Before you take Maxalt, tell your doctor or pharmacist, if: - you have any of the following risk factors for heart disease: high blood pressure, diabetes, you smoke or you are using nicotine substitution, your family has a history of heart disease, you are a man over 40 years of age, or you are a post-menopausal woman - you have kidney or liver problems - you have a particular problem with the way your heart beats (bundle branch block) - you have or have had any allergies. - If you have further questions, ask your doctor or pharmacist. - If you get any side effects talk to your doctor or pharmacist. If you are not sure if any of the above apply to you talk to your doctor or pharmacist before taking Maxalt. It may harm them, even if their signs of illness are the same as yours. This swelling results in the headache pain of a migraine attack. WHAT YOU NEED TO KNOW BEFORE YOU TAKE MAXALT Do not take Maxalt if: - you are allergic to rizatriptan benzoate or any of the other ingredients of this medicine (listed in section 6) - you have moderately severe or severe high blood pressure or mild high blood pressure that is not controlled by medication - you have or have ever had heart problems including heart attack or pain on the chest (angina) or you have experienced heart disease related signs - you have severe liver or severe kidney problems - you have had a stroke (cerebrovascular accident CVA) or mini stroke (transient ischaemic attack TIA) - you have blockage problems with your arteries (peripheral vascular disease) - you are taking monoamine oxidase (MAO) inhibitors such as moclobemide, phenelzine, tranylcypromine, or pargyline, (drugs against depression), or linezolid (an antibiotic), or if it has been less than two weeks since you stopped taking MAO inhibitors - you are now taking ergotamine-type medications, such as ergotamine or dihydro-ergotamine to treat your migraine or methysergide to prevent a migraine attack - you are taking any other drug in the same class, such as sumatriptan, naratriptan, or zolmitriptan to treat your migraine (see Other medicines and Maxalt below). Maxalt Tablets are also available in 5 mg strength. - your headache is associated with dizziness, difficulty in walking, lack of co-ordination or weakness in the leg and arm - you use herbal preparation containing St. Treatment with Maxalt: Reduces swelling of blood vessels surrounding the brain. Maxalt is used to treat the headache phase of the migraine attack in adults. WHAT MAXALT IS AND WHAT IT IS USED FOR Maxalt belongs to a class of medicines called selective serotonin 5-HT1B/1D receptor agonists. You should not use this medicine if you have uncontrolled high blood pressure, heart problems, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not take rizatriptan within 24 hours before or after using another migraine headache medicine. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Rizatriptan is a headache medicine that narrows the blood vessels around the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Rizatriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches.
The recommended starting dose of MAXALT is either 5 mg or 10 mg for the acute treatment of migraines in adults. Medscape - Indication-specific dosing for Maxalt, Maxalt MLT rizatriptan, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. 5-10 mg PO at onset of symptoms; repeat dose after 2